MIG1 AS A POSITIVE REGULATOR FOR THE HISTIDINE BIOSYNTHESIS PATHWAY AND AS A GLOBAL REGULATOR IN THERMOTOLERANT YEAST KLUYVEROMYCES MARXIANUS

MIG1 as a positive regulator for the histidine biosynthesis pathway and as a global regulator in thermotolerant yeast Kluyveromyces marxianus

Abstract Kmmig1 as a disrupted mutant of MIG1 encoding a regulator for glucose repression in Kluyveromyces marxianus exhibits a histidine-auxotrophic phenotype.Genome-wide expression analysis revealed that only HIS4 in seven HIS genes for histidine biosynthesis was down-regulated in Kmmig1.Consistently, introduction of HIS4 into Kmmig1 suppressed t

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Pharmacogenomics-guided policy in opioid use disorder (OUD) management: An ethnically-diverse case-based approach

Introduction: Opioid use disorder (OUD) is characterized by a problematic pattern of opioid use leading to clinically-significant impairment or distress.Opioid agonist treatment is an integral component of OUD management, and buprenorphine is often utilized in OUD management due to strong clinical evidence for efficacy.However, interindividual gene

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Past, present and future: Here is what we see

Brooke Aksnes, Visions convenor, writes: Here are selected extracts of the testimonies - commitments, beliefs, and aspirations - of our 19 Visions writers.They are all WN editorial team members or regular contributors.We have a balance of younger and older visionaries, Closed End Crimp Terminals women and men, and team members and regular contribut

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Nation-State Challenges in the Age of Globalization

Purpose: Nation state is a newly-constructed institution established in the wake of United States declaration of independence and has been spreading all over the world in recent centuries.But nowadays nation-state is in retreat and this is the main problem that this article aims to address.In fact, nation state causes the rudimentary development of

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